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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Horm Behav. 2007 Nov 22;53(5):693–705. doi: 10.1016/j.yhbeh.2007.11.006

Figure 3.

Figure 3

Recent studies in our laboratory indicated two AR-dependent protective pathways. First, androgens decrease levels of the AD-related protein Aβ by a classic genomic mechanism involving activated AR interaction with ARE sites on the neprilysin gene, which results in increased expression of this Aβ-catabolizing enzyme. Second, we find that androgens reduce neuronal apoptosis by an AR-dependent, non-genomic signaling cascade involving activation of MAPK/ERK, followed by activating phosphorylation (p) of Rsk, and inactivating phosphorylation of the pro-apoptotic protein Bad. Both pathways appear to involve activation of intracellular rather than membrane-associated AR.