Table 1.
The ranks and percentages of known breast cancer susceptibility genes in genome-wide ab initio prioritization
| Known disease gene | Rank in 8919 candidates |
|||
|---|---|---|---|---|
| CIPHER-SP | % | CIPHER-DN | % | |
| BRCA1 | 1 | 0.01 | 2 | 0.02 |
| AR | 3 | 0.03 | 3 | 0.03 |
| ATM | 19 | 0.21 | 4 | 0.04 |
| CHEK2 | 66 | 0.74 | 19 | 0.21 |
| BRCA2 | 139 | 1.56 | 49 | 0.54 |
| STK11 | 150 | 1.69 | 21 | 0.23 |
| RAD51 | 174 | 2.00 | 36 | 0.40 |
| PTEN | 188 | 2.10 | 24 | 0.26 |
| BARD1 | 196 | 2.20 | 41 | 0.45 |
| TP53 | 287 | 3.22 | 45 | 0.50 |
| RB1CC1 | 798 | 8.95 | 6360 | 71.30 |
| NCOA3 | 973 | 10.91 | 343 | 3.84 |
| PIK3CA | 1644 | 18.43 | 367 | 4.11 |
| PPM1D | 1946 | 21.82 | 7318 | 82.04 |
| CASP8 | 4978 | 55.81 | 2397 | 26.87 |
| TGF1 | 7116 | 79.78 | 3502 | 39.26 |