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. Author manuscript; available in PMC: 2009 Apr 8.
Published in final edited form as: Eur J Pharmacol. 2008 Feb 1;583(2-3):215–225. doi: 10.1016/j.ejphar.2007.11.075

Fig. 2.

Fig. 2

Distribution and regulatory functions depicted for CRH1 and CRH2 synaptic receptors upon excitatory synaptic transmission, [facilitatory-light gray and depressant-dark grey]. CRH1 and CRH2 receptors regulate glutamatergic transmission within synapses in the central amygdala nucleus, Left, and lateral septum medial lateral nucleus, Right. R\hCRF and Ucn I (Urocortin I), CRH1 and CRH2 receptor agonists, respectively –each produce opposite effects to inhibit or facilitate excitatory transmission-monitored as excitatory postsynaptic currents (EPSCs)-in the two different limbic nuclei, central amygdala nucleus and lateral septum mediolateral nucleus. Note low nanomolar effective concentrations. Adapted From: J. Neurosci.,24, 4020–4029.