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. Author manuscript; available in PMC: 2009 Apr 8.
Published in final edited form as: Eur J Pharmacol. 2008 Feb 1;583(2-3):215–225. doi: 10.1016/j.ejphar.2007.11.075

Fig. 3.

Fig. 3

Following chronic cocaine administrations and its withdrawal there are changes in sensitivities and functions of CRH and Ucn 1 within the lateral septal mediolateral nucleus. CRH1 receptor mediated facilitation of glutamatergic transmission persists, albeit CRH is less potent compared to control, whereas the former CRH2-mediated depression by Ucn 1 is switched to facilitation, and at comparable potency. Diagram depicts receptor distributions and functions before and after chronic cocaine at lateral septum mediolateral nucleus synapse. Adapted From: J. Neurosci.,25, 577–583.