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. Author manuscript; available in PMC: 2009 Apr 8.
Published in final edited form as: Eur J Pharmacol. 2008 Feb 1;583(2-3):215–225. doi: 10.1016/j.ejphar.2007.11.075

Fig. 4.

Fig. 4

Switch in dopamine and CRH actions after acute withdrawal from chronic cocaine. A. In saline control slices D1-like activation (SKF 81297) inhibited excitatory postsynaptic current (EPSC) amplitude; SKF 81297 effects were enhanced by addition of CRH at a concentration of CRH that did not itself affect basolateral amygdala-medial prefrontal cortex EPSCs. B. After acute withdrawal from chronic cocaine, SKF 81297 and CRH synergistically enhanced EPSC amplitude at medial prefrontal cortex synapses. Comparable results to SKF 81297 obtained with dopamine.