Table 1.

Psychopathology, physical signs and neuropsychological test results (before celecoxib)

CATEGORY		DEPRESSED EPISODE	MANIC EPISODE
Psychopathology	Mood	dysphoric, despair, anxiety	expansive, exuberant, irritable
	Drive	impaired: - most of the time in bed - social withdrawal - neglected personal hygiene - reduced self-care	increased: - seeking contacts - loss of inhibition - unnecessary purchases - booking of travels
	Thought process	brooding, difficulty making decisions, slowed thinking	logorrhoe, distractibility, poor concentration, racing thoughts
	Suicidality	passive death wishes	joie de vivre (“Lebensfreude”)
	Gestures and mimic	mask-like face and slow limb movements oculomotoric decreased sad appearing, withdrawn	rich in gestures and facial expression, oculomotoric increased, searching for eye contact and attention
	Voice	low pitched, monotonous	high pitched, melodious
	Handwriting	jittery and slow	orthographic mistakes and corrections
	Dotting	moderately impaired	normal
	Tapping	moderately impaired	moderately impaired
	HAMD	range between 31 and 38	range between 3 and 4
	BDI	range between 44 and 52	range between 3 and 5
	YMRS	range between 1 and 3	range between 21 and 24
	PANSS	range between 84 and 92	range between 40 and 41
Autonomic and physical signs	Sleep	increased requirement for sleep and daytime in bed	reduced requirement for sleep and disrupted sleep
	Appetite	decreased	increased
	Weight	decreased	increased
	Libido	absent	increased
	Allergy	no allergies	susceptibility to allergies
	Edema	no edema	edema on lower extremities
Neuropsychology	Short-term memory	mildly impaired	mildly impaired
	Long-term memory	normal	normal
	Working memory	moderately impaired	severely impaired
	Semantic fluency	moderately impaired	normal
	Executive functions	moderately impaired	severely impaired
	Psychomotor speed	moderately impaired	moderately impaired

Abbreviations: HAMD: Hamilton Rating Scale for Depression Scale; BDI: Beck Depression Inventory; YMRS: Young Mania Rating Scale; PANSS: Positive and Negative Syndrome Scale.