Figure 1.

Pur/pyr motifs present in a regulatory element of the mouse and human KRAS promoters. The sequences of the designed wild-type and twisted-intercalating TFOs are reported. Bulge insertions of (R)-1-O-[4-1-(1-pyrenylethynyl)-phenylmethyl]glycerol (TINA) have been placed between the underlined bases of the TFOs. Lower case letters indicate the bases that are linked with a thioate group to make the TFOs resistant to endogenous nucleases. The structure of the TINA intercalating unit is reported.