Figure 8.

Diagrams for hypothesized positioning of the protein and identified binding of DB293 on the various consensus-binding sites. The position of DB293 over IRF-1 (A), Brn-3 (B) and Pit-1 (C) consensus-binding sites (in red) are presented as black boxes stacking as monomers or dimers in the minor groove of the DNA. The points of interaction between the amino acids implicated in the DNA recognition and the specific target sequences are presented as dashed lanes. The water molecules implicated in the interaction are presented as full circles. In blue or pink are the DNA bases implicated in the protein direct interaction. Blue and pink dashed lanes correspond to interaction bonds within the major groove of the DNA whereas purple dashed lanes correspond to interaction bonds within the minor groove.