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. 2008 Apr 16;36(10):3214–3225. doi: 10.1093/nar/gkn148

Figure 1.

Figure 1.

Schematic representation of the Hoxa2-Hoxa1 locus and of the 1.25-kb reporter vector (A) and sequence alignment of a 100-bp region encompassing the HRE Hox-Pbx responsive element from the mouse, man, Xenopus (Xp), zebrafish (Zf), chick and horn shark (Hf) (B). The HRE sequence (open box) is shown in bold cases. (C) Sequence alignment and consensus sequence (r4 con) of known Hox–Pbx-binding sites active in the r4 territory. Black rectangles represent exons; dark grey rectangle represents the luciferase reporter gene; the open triangle shows the AUG start codon of Hoxa2; the open ellipse represents the Hox–Pbx-binding site; the open rectangle with a T shows the minimal (TATA box) promoter of the reporter construct. B: BamHI; R: EcoRI.