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. 2008 Apr 16;36(10):3214–3225. doi: 10.1093/nar/gkn148

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — The HRE element is active and responds to Hox-1 and -2 paralogues in the chick neural tube. X-gal staining reveals the expression pattern of the lacZ reporter gene under the control of the 1.25-kb region (A to F) or its mutant m1.25-kb derivative (G) in electroporated chick neural tube. Enhancement of reporter expression is observed upon co-electroporation of a Hox-1 and -2 expression vectors (B to D) while not upon Hoxd4 or HOXB7 (E, F). Deletion of either the UCE sequence (H, ΔUCE) or the intronic PH sites (I, ΔPH1-3) from the 1.25-kb region results in a loss of reporter activity. Consistently, the UCE sequence is not able to drive lacZ expression in electroporated chick neural tube on its own (J). White arrowheads show the localization of the fourth rhombomere.