Table 2.
Components of the yeast CCR4/CAF1/NOT complex, with trypanosome, human and Drosophila homologues
| Yeast | Trypanosome protein | Trypanosome GeneDB number | Humana | Drosophila CG number |
|---|---|---|---|---|
| Caf1/Pop2 | TbCAF1 | 927.6.600 | CNOT7/hCaf1a | 5684 |
| CNOT8/hCaf1b | ||||
| Ccr4 | None foundb | CNOT6/hCCR4a | 31137 | |
| CNOT6L/hCCR4b | ||||
| Not1 | TbNOT1 | 10.70.6450 | CNOT1 | 1884 |
| Not2 | TbNOT2 | 927.6.850 | CNOT2 | 2138 |
| Not3 | – | – | CNOT3S | |
| Not4 | – | – | CNOT4 N/S/L | 31716 |
| Not5 | TbNOT5 | 927.3.1920 | CNOT3L | 8426 |
| Caf4 | unclearc | Unclearc | ||
| Caf16 | – | (927.6.2810)d | ||
| Caf40 | TbCAF40 | 927.4.410 | CNOT9/hCAF40 | 14213 |
| Caf130 | ?Tb10.6k15.1820e | CNOT10 | – |
aHuman subunit names are preceded by either ‘C’ or ‘h’ (14). Ccr4a is Acc# NM_015455, Ccr4b, Acc# NM_144571, Caf1a, Acc# NM_013354, Caf1b, Acc# NM_004779.
bThe work in this article indicates that Tb927.4.2430 is not a functional homologue of Ccr4.
cSeveral possible homologues, none of which is convincing.
dUncertain.
eCaf130 has a molecular weight of 130 kDa while the Tb10.6k15.1820 protein is only 35 kDa.