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. 1997 Nov 25;94(24):13017–13022. doi: 10.1073/pnas.94.24.13017

Figure 1.

Figure 1

Axis formation is affected by siamois fusions. (A) Schematic of the siamois fusion constructs. A C-terminal region of siamois (residues 122–246), containing the homeodomain (HD), was fused to the engrailed repressor (residues 1–298) (Eng-Sia) or the VP16 activator (residues 410–490) (VP16-Sia). At the four-cell stage, one ventral (B–E, J–M) or two dorsal (F–I, N–Q) blastomeres were injected with 30 pg of β-galactosidase (B, F, J, N), siamois (C, G, K, O), VP16-Sia (D, H, L, P), or Eng-Sia (E, I, M, Q) mRNA. (J–Q) Transverse sections. See Table 1 for quantitation.