Table 2.

Phenotypes of mice genetically deficient in ADAMs

Genotype	Phenotype
ADAM8−/−	Viable and fertile with no phenotype in the unchallenged state(Kelly et al., 2005).
ADAM9−/−	Viable and fertile with no phenotype in the unchallenged state(Weskamp et al., 2002).
ADAM10−/−	Embryonic lethal (E9.5). Defects in the heart and central nervous system development and vasculogenesis (Hartmann et Al, 2002).
ADAM12−/−	30% embryonic lethal. Surviving mice have normal fertility. Minor brown fat and neck muscle hypertrophy (Kurisaki et al., 2003).
ADAM15−/−	Viable, fertile with and no phenotype in the unchallenged state. Reduced neovascularization in a murine model of retinopathy of prematurity (Horiuchi et al., 2003)
ADAM17−/−	Perinatal lethal. Epithelial dysplasia similar to that in TGF-α deficient mice with defective heart and lung development, and defective EGFR ligand shedding (Peschon et al., 1998; Zhao et Al., 2001; Shi et al., 2003).
ADAM19−/−	80% post-natal lethality 1–3 days after birth with defective heart development (Zhou et al., 2004).

Legands for table 2. TGF-α, transforming growth factor-α; EGFR, epidermal growth factor receptor.