Table 2.
Titers of hMPV in hamsters after immunization and after challenge.
| Immunizing Virusa | Mean virus titer post immunizationb (log10 PFU/gm tissue +/- SE) | Mean virus titer post challengec (log10 PFU/gm tissue +/- SE) | ||
| NT | Lungs | NT | Lungs | |
| wt hMPV/NL/1/00 | 5.9 +/- 0.3 | 4.6 +/- 1.4 | <0.4 +/- 0.1 | <0.4 +/- 0.1 |
| rhMPV | 6.0 +/- 0.6 | 5.1 +/- 0.5 | <0.4 +/- 0.1 | <0.4 +/- 0.1 |
| rhMPV/ΔM2-2 | 2.3 +/- 0.6 | 3.3 +/- 0.4 | <0.4 +/- 0.1 | <0.4 +/- 0.1 |
| placebo | ND | ND | 5.6 +/- 0.6 | 4.5 +/- 1.5 |
a Syrian golden hamsters, in groups of 8, were infected intranasally with 106 PFU/animal of the immunizing virus or placebo.
b 4 animals per group were sacrificed on day 4 p.i.. Nasal turbinates and lungs were harvested and virus titers were determined by plaque assay.
c 28 days posit immunization, 4 animals per group were challenged with 106 PFU/animal of wt hMPV/NL/1/00. 4 days post challenge, the animals were sacrificed. Nasal turbinates and lungs were harvested and virus titers were determined by plaque assay.