Table 1.
Physicochemical parameters of some polydisulfide Gd(III) complexes
| Polymeric contrast agent | Molecular weight (kDa) | Relaxivity mM−1sec−1 | PEGylation | |||
|---|---|---|---|---|---|---|
| Mw | Mn | Mw/Mn | PEG size (Da) | PEG/Gd | ||
| GDCC | 17.7 | 15.0 | 1.2 | 4.4 (1.5T) | ||
| 35.0 | 27.0 | 1.3 | 6.3 (1.5T) | |||
| GDCP | 10.1 | 10.0 | 1.0 | 5.5 (3.0T) | ||
| GDCEP | 10.2 | 9.4 | 1.1 | 5.9 (3.0T) | ||
| PEGa-GDCP | 24.5 | 21.0 | 1.2 | 16.3 (3.0T) | 2000 | 0.33 |
| PEGb-GDCP | 22.9 | 19.9 | 1.2 | 12.7 (3.0T) | 2000 | 0.76 |
| PEG2000-GDCP | 37.7 | 28.5 | 1.3 | 8.7 (3.0T) | 2000 | 1.2 |
| PEG1000-GDCP | 37.8 | 31.1 | 1.2 | 7.8 (3.0T) | 1000 | 1.3 |
| PEG550-GDCP | 33.7 | 30.8 | 1.1 | 7.8 (3.0T) | 550 | 1.3 |
Abbreviations: PEG, polyethylene glycol; GDCC, Gd-DTPA cystamine copolymer; GDCP, Gd-DTPA cystine copolymer; GDCEP, Gd-DTPA cystine diethyl ester copolymer; Mw, averaged molecular weight; Mn, averaged molecular number.