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. 2006 Sep;1(3):263–268.

Table 1.

Preclinical trials

Species Effect Reference
rhesus monkey no toxic effects, no change in intraocular pressure, no immune response to aptamer Drolet et al 2000
rhesus monkey subcutaneous and intravenous administration effective at maintaining adequate plasma levels Tucker et al 1999
guinea pig, rat, mouse, rabbit almost total inhibition of VEGF-mediated vascular permeability, reduced VEGF- induced corneal angiogenesis, reduced NV in mice with OIR Eyetech Study Group 2002
rats Suppressed leukostasis and vascular leakage in diabetics Ishida et al 2003

Abbreviations: NV, choroidal neovascularization; OIR, oxygen-induced retinopathy; VEGF, vascular endothelial growth factor.