Table 1.

Preclinical trials

Species	Effect	Reference
rhesus monkey	no toxic effects, no change in intraocular pressure, no immune response to aptamer	Drolet et al 2000
rhesus monkey	subcutaneous and intravenous administration effective at maintaining adequate plasma levels	Tucker et al 1999
guinea pig, rat, mouse, rabbit	almost total inhibition of VEGF-mediated vascular permeability, reduced VEGF- induced corneal angiogenesis, reduced NV in mice with OIR	Eyetech Study Group 2002
rats	Suppressed leukostasis and vascular leakage in diabetics	Ishida et al 2003

Abbreviations: NV, choroidal neovascularization; OIR, oxygen-induced retinopathy; VEGF, vascular endothelial growth factor.