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. 1997 Nov 25;94(24):13093–13098. doi: 10.1073/pnas.94.24.13093

Figure 2.

Figure 2

The immunophilins are not required for viability. A series of yeast strains isogenic with the wild-type strain JK93d but lacking one or more of the 12 immunophilin genes were grown on yeast extract/peptone/dextrose medium for 48 hr at 30°C. (A) Strains lacking individual cyclophilins (Δcpr1 through Δcpr8) or FKBPs (Δfpr1 through Δfpr4). (B) Strains lacking all of the cyclophilins (ΔCYPs: Δcpr1 Δcpr2 Δcpr3 Δcpr4 Δcpr5 Δcpr6 Δcpr7 Δcpr8); all the FKBPs (ΔFKBPs: Δfpr1 Δfpr2 Δfpr3 Δfpr4); all cytoplasmic immunophilins (Δcytoplasmics: Δcpr1 Δcpr6 Δcpr7 Δfpr1); all of the immunophilins localized to the secretory pathway (ΔERs: Δcpr2 Δcpr4 Δcpr5 Δcpr8 Δfpr2); the two nucleolar FKBPs (Δnucleolars: Δfpr3 Δfpr4); or all 12 cyclophilins and FKBPs (Δ12: Δcpr1 Δcpr2 Δcpr3 Δcpr4 Δcpr5 Δcpr6 Δcpr7 Δcpr8 Δfpr1 Δfpr2 Δfpr3 Δfpr4); WT, isogenic wild-type strain JK93da.