Table 1.
The yeast cyclophilins and FKBPs
| Gene (synonym) | Molecular mass | Mammalian homolog | Localization* | Characteristics/mutant phenotypes | References |
|---|---|---|---|---|---|
| Cyclophilins | |||||
| CPR1 (CYP1, CPH1) | 17 kDa | CypA | Cytoplasm | ⋅Primary receptor for CsA | (23–25, 27) |
| ⋅Induced by heat shock | |||||
| CPR2 (CYP2) | 20 kDa | CypB | Secretory pathway | ⋅Induced by heat shock and tunicamycin | (26, 27); this study |
| CPR3 (CYP3) | 20 kDa | CypD | Mitochondria | ⋅Δcpr3 has growth defect on lactate at 37° | (28–31) |
| ⋅Accelerates Su9-DHFR refolding | |||||
| CPR4 (SCC3) | 33 kDa | CypC | Secretory pathway | ⋅Induced by heat shock and tunicamycin | (32, 33); this study |
| CPR5 | 23 kDa | ER (HDEL) | ⋅Induced by tunicamycin | (34); this study | |
| CPR6 | 45 kDa | Cyp40 | Cytoplasm | ⋅Interacts with Hsp82; also interacts with Rbd3 | (44, 52, 53); this study |
| CPR7 | 45 kDa | Cyp40 | Cytoplasm | ⋅Interacts with Hsp82; also interacts with Rbd3 | (44, 52, 53); this study |
| CPR8 | 35 kDa | CypC | Secretory pathway | ⋅CPR4 homolog | This study |
| FKBPs | |||||
| FPR1 (FKB1) | 12 kDa | FKBP12 | Cytoplasm | ⋅Primary receptor for FK506 and rapamycin | (37–39) |
| ·Δfpr1 exhibits slow growth | |||||
| FPR2 (FKB2) | 12.5 kDa | FKBP13 | Secretory pathway | ⋅Induced by heat shock and tunicamycin | (35, 36) |
| FPR3 (NP146) | 70 kDa | FKBP25 | Nucleolus | ⋅Phosphorylated | (41–43) |
| ⋅Ptp1 substrate | |||||
| FPR4 | 60 kDa | FKBP25 | Nucleus | ⋅FPR3 homolog | This study |
*
Experimentally established localizations in roman text; localizations inferred by protein sequence or homology in italics.