Table 2.
Candidate loci with preliminary evidence for involvement in affective disorders based on association analyses
| Gene | General function | Candidate polymorphisms | Chromosome allocation |
|---|---|---|---|
| SLC6A4 | 5-HT reuptake | Promoter variable repeata | 17q11.1-q12 |
| TPH1 | 5-HT synthesis | A218Cb | 11p15.3-p14 |
| MAOA | 5-HT catabolism | Promoter variable repeatb | Xp11.4-911.3 |
| MTHFR | Monoamine synthesis | C677T | 1p36.3 |
| HTR1A | 5-HT receptor | C(–1019)G | 5q11.2-q13 |
| HTR1B | 5-HT receptor | C861G | 6q13 |
| A(–161)T | |||
| HTR2A | 5-HT receptor | G(–1438)A | 13q14-q21 |
| C102Tb | |||
| HTR2C | 5-HT receptor | C(–759)T | Xq24 |
| HTR3A | 5-HT receptor | C178T | 11q23.1 |
| HTR6 | 5-HT receptor | C267T | 1p36-p35 |
| GNAS1 | G-protein subunit – alpha | T131C | 20q13.2-q13.3 |
| GNB3 | G-protein subunit – beta | C825Tb | 12p13 |
| PLA2 | Phospholipase A2 | Trinucleotide repeat | 1p36.13 |
| BDNF | Neuronal growth factor | A758G | 11p13 |
| NOS1 | Neuronal nitric oxide synthesis | C29Tb | 12q24.2-q24.31 |
| CRH | Corticotropin-releasing hormone | T1273C | 8q13 |
| CRHR2 | CRH receptor | G1047A | 7p15.1 |
| SLC6A3 | Dopamine transporter | Promoter variable repeat | 5p15.3 |
| SLC6A2 | Norepinephrine transporter | Promoter variable repeat | 16q12.2 |
| ADRB1 | Norepinephrine beta 1 receptor | G145A | 10q24-q26 |
| G1165C | |||
| ADRA2A | Norepinephrine alpha 2 receptor | C(–1291)G | 10q24.q26 |
| COMT | Monoamine metabolism | G158A | 22q11.21-q11.23 |
| DRD2 | Dopamine 2 receptor | –141C insertion/deletion | 11q23 |
| CHRM2 | Muscarinic 2 receptor | A1890T | 7q31-q35 |
| APOE | Apolipoprotein E | C3937Tb | 19q13.2 |
| C4075Tb |
a
Multiple studies replicate an association with SSRI treatment response.
b
Polymorphism has a potential preliminary association with antidepressant treatment response in previous studies.
See text for citations. Gene nomenclature is according to HGNC (www.gene.ucl.ac.uk/nomenclature).