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. 2008 Jun 16;181(6):893–901. doi: 10.1083/jcb.200712028

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© 2008 Tighe et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Mps1 is required for spindle checkpoint function during an unperturbed mitosis. HeLa cells cotransfected with control or Mps1 shRNA plus a GFP–histone H2B construct were analyzed by time-lapse microscopy. (A) Image sequences showing the time in minutes from when the last chromosome aligns (arrowheads) to anaphase onset. (B) Bar graph quantifying the time taken from NEB to metaphase and from metaphase to anaphase in control and Mps1-deficient cells. Values represent the mean and SEM (error bars) derived from at least 62 cells. (C) Bar graph quantifying mitotic abnormalities observed in control or Mps1-deficient cells. Bar, 5 μm.