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. 2005 Sep 21;25(38):8746–8754. doi: 10.1523/JNEUROSCI.2809-05.2005

Figure 7.

Figure 7.

Electrocyte μEODs are modulated by a cAMP/PKA signaling pathway. A, Saline and 5-HT have no effect on μEOD amplitude and τ, whereas ACTH and the cell-permeable cAMP analog 8-Br-cAMP cause similar increases inμEOD amplitude andτ. ACTH-induced increases in μEOD amplitude and τ are eliminated or attenuated (PKI+ACTH) by pretreatment with myristoylated PKI 14–22, a cell-permeable PKA inhibitor. B, Plots summarizing μEOD amplitude andτ after 60 min of exposure to experimental conditions. Circles, horizontal lines, and vertical lines represent individual cells, means, and SEM, respectively. Conditions marked with the same letter (a or b) are not significantly different from each other. Conditions marked with different letters are statistically different. Omnibus one-way ANOVAs indicate differences among conditions for relative μEOD amplitude (F(4,19) = 8.24; p < 0.001) and relative μEOD τ (F(4,19) = 12.32; p < 0.0001). Post hoc pairwise comparisons were conducted by Fisher's least significant difference (α = 0.05).