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. Author manuscript; available in PMC: 2009 May 6.
Published in final edited form as: Eur J Pharmacol. 2008 Mar 4;585(1):2–13. doi: 10.1016/j.ejphar.2007.11.082

Figure 2. Theta burst stimulation increases numbers of spines containing dense pPAK and pCofilin.

Figure 2

(A-D) Laser confocal micrographs show spine-like profiles containing immunoreactivity for PAK3 (A), pPAK (B), Cofilin (C) and pCofilin (D) in CA1 str. radiatum of control hippocampal slices receiving only baseline stimulation. Note that elements containing dense PAK3 and Cofilin immunoreactivity are more numerous than those containing pPAK and pCofilin. Calibration bar: 5 μm. (E) Plot shows numbers of pCofilin-positive spines in proximal str. radiatum of hippocampal slices receiving control stimulation (cont, gray bar) or theta burst stimulation (TBS, white bars) with harvest at 0.5, 2-7, or 15-30 min after stimulation. The number of pCofilin-positive spines was significantly increased at 2-7 min post-theta stimulation (**p=0.008 vs cont, ANOVA followed by Tukey's HSD, n=8/group).