Fig. 1.

An example of auditory gating recorded during a control period (left panel) and following administration of the exogenous cannabinoid agonist WIN55,212-2 (right panel). The auditory evoked LFP responses, averaged over 128 trials, were recorded from the hippocampal CA3 region of an anesthetized rat. The two auditory 3 kHz tones presented 500 ms apart, are indicated by the arrows. Left panel: during the control period the rat exhibited normal gating with a T/C ratio of 0.50. Right panel: after administration of the non-selective cannabinoid agonist WIN55,212-2, a loss of sensory gating was observed, indicated by the higher T/C value of 0.81