Table 4.
CYP2C9 and VKORC1 Combined Genotype Frequencies
| AJ |
SJ |
||||||
|---|---|---|---|---|---|---|---|
| CYP2C9 Genotype (Predicted Metabolizer Phenotypea) | VKORC1 g.-1639G→A | nb | Frequency (%) | No. of p.D36Y Carriers | nb | Frequency (%) | No. of p.D36Y Carriers |
| ∗1/∗1 (EM) | |||||||
| G/G | 49 | 18.8 | 9c | 9 | 11.3 | 1 | |
| G/A | 81 | 31.2 | 10 | 14 | 17.5 | 0 | |
| A/A | 38 | 14.6 | 0 | 13 | 16.3 | 0 | |
| ∗1/∗2 or ∗1/∗3 (IM) | |||||||
| G/G | 26 | 10.0 | 2 | 11 | 13.8 | 0 | |
| G/A | 38 | 14.6 | 3 | 17 | 21.3 | 0 | |
| A/A | 20 | 7.7 | 0 | 6 | 7.5 | 0 | |
| ∗2/∗2, ∗2/∗3, or ∗3/∗3 (PM) | |||||||
| G/G | 1 | 0.4 | 1 | 2 | 2.5 | 0 | |
| G/A | 6 | 2.3 | 2 | 5 | 6.3 | 0 | |
| A/A | 1 | 0.4 | 0 | 3 | 3.8 | 0 | |
a
EM, extensive metabolizer; IM, intermediate metabolizer; and PM, poor metabolizer.
b
Number of subjects.
c
One p.D36Y homozygote was found in this group.