Figure 4. Dynamics can be characterized by a multi-state kinetic mechanism.

Important time scales in scaffold mediated signaling. (A) Graph of multi-state kinetic model whose dynamics are governed by 8 transitions. Each kinase can transition between four states denoted with four subscripts: in solution (S), bound to a signaling competent complex (C), bound to a signaling incompetent complex (I), and activated (A). (B) Diagram depicting how the various processes occurring at fast time scales couple with scaffold concentration ζ to give rise to collective behavior occurring at slower time scales.