Table 1. Modulation of MDM gene expression caused by L. chagasi infection.
| MDM: up-regulated transcripts (9 of 54,675 probe sets†) | ||||
| Symbol | Description | Cytoband | Fold Change | % False Positive |
| CXCL-5 | chemokine (C-X-C motif) ligand 5 | 4q12-q13 | 2.628 | 0.012 |
| Metallothioneins | ||||
| MT1M, F, G | metallothionein 1M, 1F, 1G | 16q13 | 2.7–21.146 | 0–0.05 |
| Cell Metabolism | ||||
| APOBEC-3A | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | 22q13.1-q13.2 | 2.578 | 0.013 |
| ST3GAL3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3 | 1p34.1 | 5.267 | 0.015 |
| AFF4 | AF4/FMR2 family, member 4 | 5q31 | 1.851 | 0.015 |
| IFI44L | interferon-induced protein 44-like | 1p31.1 | 2.094 | 0.049 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 10p15-p14 | 1.541 | 0.054 |
| MDM: down-regulated transcripts (selected from 72 of 54,675 probe sets†) | ||||
| Cell Regulation | ||||
| MLL | myeloid/lymphoid or mixed-lineage leukemia | 11q23 | 0.373 | 0.016 |
| YAF-2 | YY1 associated factor 2 | 12q12 | 0.453 | 0.012 |
| eIF2C3 | translation initiation factor 2C | 1p34.3 | 0.420 | 0.031 |
| Protein Metabolism | ||||
| PHGDH | phosphoglycerate dehydrogenase | 1p12 | 0.343 | 0.011 |
| FMNL3 | formin-like 3 | 12q13.12 | 0.394 | 0.014 |
| DPEP2 | dipeptidase 2 | 16q22.1 | 0.373 | 0.018 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 6q13-q14.3 | 0.455 | 0.040 |
| Immune Response | ||||
| IL1-R2 | interleukin 1 receptor, type II | 2q12-q22 | 0.200–0.425 | 0–0.028 |
| TNFSF-15 | tumor necrosis factor (ligand) superfamily, member 15 | 9q32 | 0.311 | 0.0071 |
| SIGLEC-10 | sialic acid binding Ig-like lectin 10 | 19q13.3 | 0.374 | 0.014 |
| Kinase Activity | ||||
| PCTK2 | PCTAIRE protein kinase 2 | 12q23.1 | 0.383 | 0.013 |
| PAK1 | p21/Cdc42/Rac1-activated kinase 1 | 11q13-q14 | 0.396 | 0.015 |
| TNFRSF-10B | tumor necrosis factor receptor superfamily, member 10b | 8p22-p21 | 0.436 | 0.018 |
| Other | ||||
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 9q34.3 | 0.478 | 0.048 |
| TFRC | transferrin receptor (p90, CD71) | 3q29 | 0.357 | 0.012 |
| ATG16L2 | ATG16 autophagy related 16-like 2 | 11q13.4 | 0.340 | 0.014 |
| PRDX6 | peroxiredoxin 6 | 1q25.1 | 0.398 | 0.017 |
Genes were selected from the overall list of probe sets found to be differentially regulated by RankProd with a PFP <0.05 and functionally clustered with DAVID.
†: 54,675 probe sets were analyzed, and the indicated number were selected as significantly (PFP<0.05) changed between infected and noninfected macrophages.