Table 1.
Descriptive Characteristics of Study Subjects by Cohort of Origin
| Cohort (Country of Origin) | Diagnosis Criteria | Number in Discovery Sample (Pooled GWAS) | Number in Replication Studies | Number in Meta-analysis | Age Years (SD) | BMI kg/m2 (SD) |
|---|---|---|---|---|---|---|
| Chingford study (UK) | Population-based, radiographic knee OA | 114 Fa OA, 196 F controls | 146 F OA, 243 F controls | 260 F OA, 439 F controls | 64.0 years (SD = 6.0) | 26.7 kg/m2 (SD = 4.6). |
| Case control (UK) | Clinical knee OA and age-matched controls | 243 F OA, 52 F controls, 37 Ma controls | 258 F OA, 402 F controls | 501 F OA, 454 F OA | 73.0 years (SD = 8.5) | 27.7 kg/m2 (SD = 4.7) |
| TwinsUK (UK) | Population-based, radiographic knee OA | 0 | 195 F OA, 885 F controls | 165b F OA, 679b F controls | 65.0 years (SD = 13.1) | 25.1 kg/m2 (SD = 4.4) |
| Case control (US) | Clinical knee OA and age-matched controls | 0 | 272 F OA, 258 F controls | 272 F OA, 258 F controls | 60.5 years (SD = 8.9) | 28.8 kg/m2 (SD = 4.9) |
| Rotterdam study (Netherlands) | Population-based, radiographic knee OA | 0 | 306 F OA, 584 F controls | 306 F OA, 584 F controls | 68.3 years (SD = 8.0) | 26.7 kg/m2 (SD = 4.1) |
a
F, female; M, male.
b
Number of singletons.