Lymphocyte Telomere Lengths
(A) Lymphocyte telomere lengths measured by flow-FISH of family A, including generation III affected individuals (red filled squares), generation III silent carriers (red open squares), unaffected members of generation III (blue filled diamonds), and unaffected members of generations I and II (blue open diamonds). The black line indicates the first percentile, and the blue line indicates the 99th percentile. Individual III-05 (filled red square on the first percentile line) had telomere lengths of 5.2 kb. The first percentile for age is 5 kb. However, his telomere lengths were less than the first percentile for age in naive T cells and granulocytes (data not shown).
(B) Lymphocyte telomere lengths of the four unrelated DC probands (filled red circles) with TINF2 mutations, their unaffected parents (open blue diamonds), and unaffected siblings (filled blue diamonds).