Table 2.

Summary of Comparisons of Relative Levels of PTEN Transcript, miR-19a, and miR-21 Expression among Control Samples and PTEN-Mutation-Positive and PTEN-Mutation-Negative Patient and Patient Subgroup Samples

	PTEN	miR-19a	miR-21
PTEN+	0.015	0.003	0.006
R130X	< 0.001	0.037	0.044
R233X	< 0.001	0.015	0.184
R335X	0.287	0.137	0.147
PTEN+ dec. versus PTEN+ norm.	0.336	0.009	0.003
R130X/R233X dec. versus R130X/R233X norm.	0.234	0.020	0.008
PTEN+ CS	0.069	0.006	0.013
PTEN+ CSL	0.055	0.034	0.085
PTEN+ BRRS	0.209	0.932	0.772
PTEN−	0.969	< 0.001	0.141
PTEN− CS	0.900	< 0.001	0.835
PTEN− CSL	0.544	< 0.001	0.018
PTEN− BRRS	0.148	0.492	0.215
PTEN+ versus PTEN−	0.001	0.977	< 0.001
PTEN+ CS versus PTEN− CS	0.020	0.878	0.015
PTEN+ CSL versus PTEN− CSL	0.079	0.368	0.029
PTEN+ BRRS versus PTEN− BRRS	0.067	0.496	0.326

p values were determined from t tests comparing the relative expression of PTEN, miR-19a, and miR-21 between controls and patients or patient subgroups, except where indicated. Significant results are indicated as underlined.

“PTEN+” denotes PTEN-mutation-positive patients.

“PTEN−” denotes PTEN-mutation-negative patients.

“PTEN+ dec.” denotes PTEN+ patients with decreased PTEN protein expression. PTEN protein status “calls” are illustrated in Figure S1.

“PTEN+ norm.” denotes PTEN+ patients with normal PTEN protein expression. PTEN protein status “calls” are illustrated in Figure S1.

“R130X/R233X dec.” denotes patients with R130X and/or R233X mutations with decreased PTEN protein expression.

“R130X/R233X norm.” denotes patients with R130X and/or R233X mutations with normal PTEN protein expression.