Figure 4.

Bare Lymphocyte Syndrome Type 1 Protein-Interaction Network

The protein-interaction network associated with bare lymphocyte syndrome type 1, which comprises the genes TAP1, TAP2, and TAPBP. Each of these genes is shown in red. The DI and SP methods additionally identified the unrelated genes PSMB8 and PSMB9 (shown in yellow) as potential disease genes because they each have an interaction with one of the true disease genes. The RWR method ranks the true disease genes higher because each true disease gene has interactions with two other family members and because there is a dense net of proteins that connect the disease genes via paths with two interactions. All proteins connected to the correct or incorrect candidates by a single interaction are additionally displayed. The graphic was generated with Cytoscape.⁴⁴