Table 3.
Cage and Exploratory Activity and Passive-Avoidance Learning in Limp2-Deficient Mice and Controls
| Test Measure | Limp2+/+ | Limp2−/− | p Value∗ |
|---|---|---|---|
| Cage activity (counts/24 hr) | 6135 ± 851 | 10342 ± 1225 | p = 0.022∗∗ |
| Open Field | |||
| Path length (cm) | 1197 ± 265 | 2731 ± 612 | p = 0.15 |
| Corner crossings | 37 ± 9 | 63.8 ± 14.6 | p = 0.17 |
| Latency of center entry (s) | 284 ± 130 | 166 ± 110.7 | p = 0.5 |
| Number of center entries | 4.8 ± 3.2 | 11.6 ± 5.2 | p = 0.3 |
| Social Exploration | |||
| Latency of center entry (s) | 172 ± 109 | 171 ± 113 | p = 0.99 |
| Number of center entries | 11 ± 5 | 14 ± 5 | p = 0.7 |
| Elevated Plus Maze | |||
| Percentage of time in open arms | 33 ± 8 | 32 ± 4 | p = 0.9 |
| Percentage of counts in open arms | 35 ± 5 | 26 ± 4 | p = 0.21 |
| Passive-Avoidance Learning | |||
| Step-through latency (s) | 156 ± 59 | 159 ± 57 | p = 0.97 |
All data are means ± SEM.
∗
Values are determined by two-tailed t test except where indicated.
∗∗
This value is determined by repeated measures ANOVA, effect of genotype.