Table 2.
The Value of the Exponential-Decay Constant C in Equation 2 Computed for Various Simulation Parameters
| Number of Stem Cells | mtDNA Copy Number, Nt | mtDNA Half-Life, Thalf (Days) | Initial Mutation Level, m (%) | C |
|---|---|---|---|---|
| 20,000 | 1,000 | 10 | 30 | 1.4251 |
| 20,000 | 1,000 | 10 | 70 | 1.4212 |
| 20,000 | 1,000 | 20 | 30 | 1.5234 |
| 20,000 | 1,000 | 20 | 70 | 1.5459 |
| 20,000 | 2,000 | 10 | 30 | 1.3870 |
| 20,000 | 2,000 | 10 | 70 | 1.3662 |
| 20,000 | 2,000 | 20 | 30 | 1.5530 |
| 20,000 | 2,000 | 20 | 70 | 1.4423 |
| 2,000,000 | 1,000 | 10 | 30 | 1.4075 |
The parameters Nt, Thalf, and the initial heteroplasmy levels were varied. The mean decay constant in these simulations was C = 1.45, with standard deviation = 0.07.