Table 1.
Demographic Data Associated with Frontal-Cortex Brain-Tissue Samples Utilized in this Study
| CTRL | SZ | BD | |
|---|---|---|---|
| Number of Tissue Samples | 35 | 35 | 35 |
| Number Hybridized | 28 | 35 | 32 |
| Mean Age and Range | 44.1 (31-59) | 42.6 (19-59) | 45.3 (19-64) |
| Race | 35 white | 35 White | 33 White 1 Black 1 Native American |
| Sex | 26M, 9F | 26M, 9F | 17M, 18F |
| Diagnosis | no axis I | 27 undifferentiated 7 paranoid 1 disorganized | 26 BP I 4 BP II 4 BP NOS 1 BP-SA |
| Psychotic Features | 0 | 35+ | 20+, 11−, 4 unclear |
| Cause of Death | 32 cardiac 3 other medical | 14 cardiac 13 other medical 1 accident 7 suicide | 12 cardiac 4 other medical 4 accidents 15 suicide |
| Postmortem Interval | Male: 26.9 (11.7) Female: 35.50 (9.6) | Male: 31.4 (17.0) Female: 30.88 (9.1) | Male: 37.8 (20.6) Female: 39.59 (17.7) |
| Refrigerator Interval | Male: 2.9 (1.6) Female: 2.83 (0.4) | Male: 5.67 (4.3)∗ Female: 6.25 (4.1) | Male: 7.80 (7.4)∗ Female: 13.18 (12.7)∗ |
| Brain pH | Male: 6.65 (0.26) Female: 6.45 (0.30) | Male: 6.44 (0.25)∗ Female: 6.61 (0.17) | Male: 6.46 (0.26)∗ Female: 6.44 (0.29) |
| Brain Weight | Male: 1486.4 (137.9) Female: 1314.2 (106.3) | Male: 1444.6 (104.8) Female: 1418.1 (128.8) | Male: 1467.6 (112.9) Female: 1316.2 (111.4) |
| Lifetime Alcohol Use | Male: 0.73 (0.94) Female: 1.00 (1.55) | Male: 2.36 (2.00)∗∗ Female: 1.38 (2.00) | Male: 2.86 (1.70)∗∗ Female: 2.29 (1.86)∗ |
| Lifetime Drug Use | Male: 0.27 (0.70) Female: 0.17 (0.41) | Male: 2.08 (2.00)∗∗ Female: 0.29 (0.76) | Male: 2.93 (2.05)∗∗ Female: 1.76 (1.8)∗ |
Summary of demographic data for the brain samples obtained from the Stanley Foundation. Comparison of brain samples utilized for microarray-based epigenomic profiling. Given are the mean for each group (with SD). Affected individuals were found to have significantly lower brain pH (male SZ, male BD) and higher lifetime alcohol and drug use (male SZ, male BD, female BD) compared to unaffected controls of the same sex, reflecting data reported elsewhere. None of these demographic variables was correlated with DNA methylation.
∗denotes a t test of p < 0.05 comparing affected group with controls.
∗∗denotes a t test of p < 0.001 comparing affected group with controls.