Table 1.
SNPs, Beta Coefficients, and p Values associated with Plasma CRP Levels in the Women's Genome Health Study
|
WGHS-1 (N = 4418) |
WGHS-2 (N = 1927) |
WGHS-Combined (N = 6345) |
||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Loci | SNP | Beta | p value | Beta | p Value | Beta | p Value |
| LEPR | 1q31.3 | rs1892534 | −0.173 | 1.53 × 10−15 | −0.166 | 3.74 × 10−7 | −0.170 | 6.52 × 10−21 |
| rs2889195 | −0.171 | 5.04 × 10−15 | −0.166 | 4.51 × 10−7 | −0.168 | 2.78 × 10−20 | ||
| rs2211651 | −0.170 | 7.45 × 10−15 | −0.168 | 3.32 × 10−7 | −0.168 | 3.10 × 10−20 | ||
| rs12753193 | −0.157 | 6.91 × 10−13 | −0.151 | 5.03 × 10−6 | −0.154 | 3.27 × 10−17 | ||
| rs2186245 | −0.176 | 5.41 × 10−11 | −0.156 | 2.39 × 10−4 | −0.168 | 1.27 × 10−13 | ||
| rs12022410 | 0.126 | 4.03 × 10−9 | 0.137 | 2.43 × 10−5 | 0.128 | 7.48 × 10−13 | ||
| rs7539471 | 0.115 | 5.33 × 10−7 | 0.140 | 5.52 × 10−5 | 0.122 | 1.87 × 10−10 | ||
| rs4291477 | 0.107 | 5.95 × 10−7 | 0.122 | 1.80 × 10−4 | 0.110 | 7.65 × 10−10 | ||
| rs4655537 | 0.112 | 6.42 × 10−7 | 0.110 | 9.14 × 10−4 | 0.110 | 3.28 × 10−9 | ||
| CRP | 1q23.2 | rs3091244 | 0.207 | 1.45 × 10−20 | 0.193 | 7.63 × 10−9 | 0.203 | 6.16 × 10−28 |
| rs1205 | −0.205 | 5.47 × 10−20 | −0.184 | 5.93 × 10−8 | −0.199 | 1.65 × 10−26 | ||
| rs7553007 | −0.207 | 2.68 × 10−20 | −0.179 | 1.35 × 10−7 | −0.199 | 2.16 × 10−26 | ||
| rs2794520 | −0.202 | 2.18 × 10−19 | −0.185 | 4.33 × 10−8 | −0.197 | 4.74 × 10−26 | ||
| rs2027471 | −0.200 | 3.00 × 10−19 | −0.164 | 1.13 × 10−6 | −0.190 | 1.97 × 10−24 | ||
| rs2592887 | −0.162 | 4.78 × 10−14 | −0.151 | 3.65 × 10−6 | −0.159 | 1.04 × 10−18 | ||
| rs1417938 | 0.146 | 2.90 × 10−10 | 0.178 | 4.40 × 10−7 | 0.156 | 9.72 × 10−16 | ||
| rs3116653 | 0.147 | 2.23 × 10−10 | 0.176 | 6.39 × 10−7 | 0.156 | 9.91 × 10−16 | ||
| rs3116636 | 0.147 | 2.59 × 10−10 | 0.176 | 5.69 × 10−7 | 0.155 | 1.06 × 10−15 | ||
| rs3122012 | 0.145 | 4.22 × 10−10 | 0.176 | 6.34 × 10−7 | 0.154 | 1.95 × 10−15 | ||
| rs3116651 | 0.145 | 5.27 × 10−10 | 0.181 | 4.26 × 10−7 | 0.155 | 1.91 × 10−15 | ||
| rs3116656 | 0.144 | 5.45 × 10−10 | 0.175 | 6.97 × 10−7 | 0.153 | 2.78 × 10−15 | ||
| rs1800947 | −0.300 | 3.90 × 10−12 | −0.241 | 2.40 × 10−4 | −0.283 | 5.08 × 10−15 | ||
| rs12093699 | 0.132 | 1.60 × 10−8 | 0.126 | 2.95 × 10−4 | 0.130 | 2.15 × 10−11 | ||
| rs12068753 | 0.286 | 2.17 × 10−10 | 0.149 | 3.72 × 10−2 | 0.249 | 6.70 × 10−11 | ||
| rs3093075 | 0.280 | 4.82 × 10−10 | 0.160 | 2.52 × 10−2 | 0.248 | 7.72 × 10−11 | ||
| rs3093059 | 0.284 | 2.77 × 10−10 | 0.146 | 4.06 × 10−2 | 0.247 | 9.28 × 10−11 | ||
| rs11265260 | 0.289 | 5.64 × 10−10 | 0.150 | 3.63 × 10−2 | 0.249 | 1.99 × 10−10 | ||
| rs3093068 | 0.274 | 1.45 × 10−9 | 0.158 | 2.80 × 10−2 | 0.243 | 2.34 × 10−10 | ||
| rs12744244 | 0.127 | 3.04 × 10−6 | 0.121 | 1.81 × 10−3 | 0.123 | 3.12 × 10−8 | ||
| IL6R | 1q21.3 | rs8192284 | −0.095 | 1.09 × 10−5 | −0.119 | 2.81 × 10−4 | −0.101 | 1.93 × 10−8 |
| rs4129267 | −0.096 | 9.33 × 10−6 | −0.117 | 3.54 × 10−4 | −0.101 | 1.97 × 10−8 | ||
| GCKR | 2p23.3 | rs780094 | 0.142 | 3.97 × 10−11 | 0.136 | 3.80 × 10−5 | 0.140 | 6.73 × 10−15 |
| rs1260326 | 0.136 | 2.18 × 10−10 | 0.139 | 3.18 × 10−5 | 0.16 | 3.57 × 10−14 | ||
| rs1260333 | 0.112 | 4.69 × 10−7 | 0.106 | 1.65 × 10−3 | 0.110 | 2.69 × 10−9 | ||
| Unknown | 12q23.2 | rs10778213 | −0.109 | 3.65 × 10−7 | −0.128 | 7.00 × 10−5 | −0.115 | 1.16 × 10−10 |
| rs2292996 | −0.089 | 2.96 × 10−5 | −0.113 | 4.87 × 10−4 | −0.096 | 5.98 × 10−8 | ||
| HNF1A | 12q24.31 | rs7310409 | −0.120 | 4.63 × 10−8 | −0.237 | 1.81 × 10−12 | −0.154 | 6.75 × 10−17 |
| rs735396 | −0.117 | 1.70 × 10−7 | −0.223 | 1.12 × 10−12 | −0.147 | 5.39 × 10−15 | ||
| rs1169300 | −0.112 | 1.81 × 10−6 | −0.230 | 1.64 × 10−10 | −0.146 | 1.15 × 10−13 | ||
| rs2464196 | −0.108 | 4.37 × 10−6 | −0.231 | 1.44 × 10−10 | −0.143 | 3.32 × 10−13 | ||
| rs7953249 | −0.102 | 2.67 × 10−6 | −0.201 | 1.42 × 10−9 | −0.130 | 6.98 × 10−13 | ||
| rs2650000 | −0.093 | 3.64 × 10−5 | −0.198 | 9.90 × 10−9 | −0.123 | 7.13 × 10−11 | ||
| rs1169302 | −0.094 | 1.23 × 10−5 | −0.148 | 6.36 × 10−6 | −0.110 | 9.29 × 10−10 | ||
| rs1169307 | 0.100 | 7.19 × 10−6 | 0.112 | 9.14 × 10−4 | 0.103 | 2.90 × 10−8 | ||
| APOE | 19q13.32 | rs769449 | −0.276 | 8.57 × 10−17 | −0.227 | 1.09 × 10−5 | −0.261 | 8.90 × 10−21 |
| rs2075650 | −0.213 | 4.65 × 10−12 | −0.200 | 2.37 × 10−5 | −0.209 | 6.80 × 10−16 | ||
Adjustments made for age, smoking status, body-mass index, hormone-therapy use, and menopausal status.