Table 2.
Nonredundant SNPs in Each of Seven Loci that Contribute to Adjusted CRP Levels in Backward-Selection Models
| Median hsCRP Level (mg/l) |
Locus-wideVariance |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Chromosome | Position | MAF | HW | A1-A2 | A1A1 | A1A2 | A2A2 | Explained (%) |
| LEPR | rs1892534 | 1 | 65878531 | 0.384 | 0.11 | A-G | 1.40 | 1.88 | 2.09 | 1.6 |
| rs12753193 | 1 | 65942266 | 0.375 | 0.11 | G-A | 1.41 | 1.88 | 2.08 | ||
| rs7539471 | 1 | 65957990 | 0.315 | 0.25 | A-G | 2.24 | 1.91 | 1.79 | ||
| rs12409877 | 1 | 65716459 | 0.392 | 0.16 | A-G | 1.69 | 1.82 | 2.07 | ||
| rs5010905 | 1 | 65971810 | 0.260 | 0.03 | G-A | 2.15 | 1.97 | 1.80 | ||
| CRP | rs3091244 | 1 | 157951288 | 0.360 | 0.94 | T/A-G∗ | 2.41 | 2.03 | 1.66 | 3.4 |
| rs1800947 | 1 | 157950061 | 0.065 | 0.92 | G-C | 0.73 | 1.61 | 1.95 | ||
| rs3122012 | 1 | 157955946 | 0.302 | 0.95 | G-A | 2.25 | 2.04 | 1.74 | ||
| rs3093059 | 1 | 157951759 | 0.059 | 0.91 | G-A | 2.05 | 2.34 | 1.84 | ||
| rs4131568 | 1 | 157988679 | 0.334 | 0.37 | A-G | 2.11 | 1.98 | 1.77 | ||
| rs3116654 | 1 | 157962384 | 0.126 | 0.22 | G-A | 1.22 | 1.65 | 1.99 | ||
| rs863013 | 1 | 157466643 | 0.330 | 0.60 | A-C | 1.66 | 1.82 | 2.01 | ||
| IL6R | rs4129267 | 1 | 152692887 | 0.398 | 0.20 | A-G | 1.65 | 1.95 | 1.98 | 0.6 |
| rs12750774 | 1 | 152783100 | 0.304 | 0.29 | A-G | 1.63 | 1.84 | 2.01 | ||
| GCKR | rs780094 | 2 | 27594740 | 0.401 | 0.07 | A-G | 2.17 | 1.92 | 1.74 | 1.1 |
| rs1260333 | 2 | 27602127 | 0.453 | 0.74 | A-G | 2.11 | 1.86 | 1.81 | ||
| rs780106 | 2 | 27535101 | 0.382 | 0.04 | C-A | 1.81 | 1.86 | 1.98 | ||
| rs1647266 | 2 | 27546988 | 0.382 | 0.04 | G-A | 1.81 | 1.87 | 1.98 | ||
| rs13013484 | 2 | 27842324 | 0.270 | 0.67 | G-A | 1.62 | 1.82 | 1.98 | ||
| Unknown | rs10778213 | 12 | 102019280 | 0.468 | 0.71 | G-A | 1.75 | 1.85 | 2.08 | 0.8 |
| rs4433630 | 12 | 102174160 | 0.487 | 0.69 | A-G | 1.80 | 187 | 2.05 | ||
| HNF1A | rs7310409 | 12 | 119909243 | 0.388 | 0.28 | A-G | 1.66 | 1.78 | 2.15 | 1.1 |
| rs1169300 | 12 | 119915607 | 0.295 | 0.45 | A-G | 1.78 | 1.74 | 2.07 | ||
| rs2464196 | 12 | 119919809 | 0.294 | 0.43 | A-G | 1.80 | 1.73 | 2.07 | ||
| rs1169302 | 12 | 119916684 | 0.425 | 0.49 | C-A | 1.68 | 1.86 | 2.09 | ||
| APOE | rs769449 | 19 | 50101841 | 0.115 | 0.51 | A-G | 1.38 | 1.46 | 2.00 | 1.5 |
| rs157580 | 19 | 50087105 | 0.392 | 0.13 | G-A | 2.05 | 1.94 | 1.76 | ||
Adjustments made for age, smoking status, body-mass index, hormone-therapy use, and menopausal status.
Also shown are the crude median blood levels of hsCRP observed among homozygous carriers of the minor allele (A1A1), heterozygotes (A1A2), and homozygous carriers of the major allele (A2A2) for each selected SNP, and the loci-wide variance in CRP is explained.
MAF denotes “minor-allele frequency.”
HW indicates significance of deviation from Hardy-Weinberg equilibrium.
Selection criteria and methods to identify lead SNPs described in text.
∗
Tri-allelic SNP. The two less-common alleles (T/A) were pooled.