Table 3.
Global Bayes Factors for Candidate Genes Showing Strongest Evidence of Association with C-Reactive Protein in CHS
| Gene | Gene # | Chr. | Position | # SNPs Typed | Description | Log10 Bayes Factor | p Value (Permutation) |
|---|---|---|---|---|---|---|---|
| CRP | 1401 | 1 | 157,948,704–157,951,003 | 4 | C-reactive protein | 24.8 | < 1 × 10−6 |
| APOE | 348 | 19 | 50,100,879–50,104,489 | 2 | Apolipoprotein E | 9.9 | < 1 × 10−6 |
| HNF1A | 6927 | 12 | 119,900,932–119,924,695 | 8 | Transcription factor 1; hepatic nuclear factor (HNF)-1α | 7.7 | < 1 × 10−6 |
| PARP1 | 142 | 1 | 224,615,129–224,662,414 | 9 | Poly (ADP-ribose) polymerase family, member 1 | 0.7 | 0.012 |
| CEBPD | 1052 | 8 | 48,812,029–48,813,279 | 1 | CCAAT/enhancer binding protein delta | 0.7 | 0.016 |
| ATF3 | 467 | 1 | 210,848,617–210,860,737 | 15 | Activating transcription factor 3 | 0.5 | 0.012 |
| GP6 | 51206 | 19 | 60,216,887–60,241,444 | 8 | glycoprotein VI (platelet) | 0.4 | 0.017 |
| CPB2 | 1361 | 13 | 45,525,323–45,577,212 | 11 | Carboxypeptidase B2 | 0.3 | 0.016 |
| SP1 | 6667 | 12 | 52,060,246–52,096,493 | 5 | Sp1 transcription factor | 0.3 | 0.039 |
| IL6 | 3569 | 7 | 22,732,028–22,738,091 | 7 | Interleukin-6 | 0.3 | 0.021 |
| TIRAP | 114609 | 11 | 125,658,192–125,670,038 | 8 | Toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.2 | 0.048 |
| F7 | 2155 | 13 | 112,808,106–112,822,995 | 5 | Coagulation factor VII | 0.2 | 0.046 |
| IL1RN | 3557 | 2 | 113,591,941–113,608,063 | 11 | Interleukin-1 receptor antagonist | 0.2 | 0.045 |
| F2 | 2147 | 11 | 46,697,331–46,717,631 | 7 | Coagulation factor II precursor | 0.2 | 0.042 |
| PROZ | 8858 | 13 | 112,860,969–112,874,695 | 31 | protein Z, vitamin K-dependent plasma glycoprotein | 0.1 | 0.034 |
| HMOX1 | 3162 | 22 | 34,107,087–34,120,194 | 8 | heme oxygenase (decycling) 1 | 0.1 | 0.034 |
| PNPT1 | 87178 | 2 | 55,715,971–55,774,463 | 9 | Polyribonucleotide nucleotidyltransferase 1 | 0.02 | 0.042 |
Global Bayes Factors test the null hypothesis of no association between any SNP in the candidate-gene region versus the alternative that one SNP is associated, and are given by the average of the single-SNP Bayes Factors in the region7.