Table 4.
HNF1A SNPs Typed in CHS and their Associations with Plasma Log(CRP) Concentration
| rs # | Chr. 12 Coordinate | Location | Alleles | Minor-Allele Frequency | Number with Nonmissing Genotype and CRP Phenotype | Regression Coefficient (95% CI) | Single-SNP Bayes Factor Log(10) | Nominal p Value |
|---|---|---|---|---|---|---|---|---|
| rs1169288 | 119901033 | Exon 1 (Ile27Leu) | A/C | 0.28 | 4328 | −0.12 (−0.07 to −0.16) | +6.0 | 2.6 × 10−7 |
| rs1169286 | 119903439 | Intron 1 | T/C | 0.36 | 4332 | −0.10 (−0.06 to −0.15) | +4.8 | 1.6 × 10−6 |
| rs1169293 | 119910928 | Intron 1 | A/G | 0.11 | 4332 | −0.11 (−0.03 to 0.19) | +0.9 | 0.008 |
| rs12427353 | 119911284 | Intron 2 | G/C | 0.17 | 4333 | +0.09 (0.04 to 0.14) | +1.7 | 0.001 |
| rs2071190 | 119915655 | Intron 2 | T/A | 0.23 | 4333 | +0.04 (−0.01 to 0.09) | +1.0 | 0.16 |
| rs2464196 | 119919810 | Exon 7 (Ser486Asn) | G/A | 0.28 | 4329 | −0.11 (−0.06 to −0.16) | +6.3 | 1.9 × 10−6 |
| rs1169303 | 119920759 | Intron 7 | A/C | 0.47 | 4330 | −0.11 (−0.06 to −0.15) | +4.9 | 9.7 × 10−7 |
| rs1169310 | 119923816 | 3′ UTR | G/A | 0.38 | 4330 | −0.13 (−0.08 to −0.17) | +8.6 | 1.7 × 10−8 |
Estimates, 95%CI, and p-values were derived from single-SNP multiple linear regression models.
Regression coefficients estimate the increase/decrease in log(CRP) level per each additional copy of the minor allele, adjusted for age, sex, clinic, body mass index, and smoking.