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Views of the ligand-binding site of P450 2C8 illustrating interactions of (R)-felodipine (A and B) or 9-cis-retinoic acid (C and D) with the protein. The proximal molecule of retinoic acid is designated as RA1, and the distal molecule is labeled as RA2. The atom color code is the same as described in the legend of Fig. 2.
