TABLE 1.
Names and description of reqIgG7 mutants
| Mutant | Descriptiona | eqIgG subclasses carrying the same residues as those substituted |
|---|---|---|
| M252K | Met252 in CH2 domain substituted with Lys | IgG5 |
| K382Q | Lys382 in CH3 domain substituted with Gln | IgG1, IgG2, IgG3, IgG5, IgG6 |
| HN433/434EH | His433 in CH3 domain substituted with Glu, Asn434 in CH3 domain substituted with His | Glu433 in IgG5 |
| H433R | His433 in CH3 domain substituted with Arg | IgG6 |
| HY435/436TV | His435 in CH3 domain substituted with Thr, Tyr436 in CH3 domain substituted with Val | Thr435 in IgG6 |
| Val436 in IgG3 |
a
Numbering corresponds to human IgG1 numbering.