FIGURE 1.

Assembly and activation of the phagocyte NADPH oxidase. In resting phagocytes, heterodimeric gp91^phox-p22^phox resides in the membrane, whereas the complex of p47^phox-p67^phox-p40^phox is cytosolic. Agonist-triggered phosphorylation of the autoinhibitory domain of p47^phox (series of small boxes) releases a conformational restriction, making interactive protein motifs, including the PX domain, Src homology 3 regions (SH3), and proline-rich regions (PRR), in p47^phox accessible to associate at the membrane and to mediate oxidase assembly. See text for additional details.