Figure 3.
In vivo imaging with microPET/CT demonstrates rapid tumor formation. (A) microCT reconstruction of an animal with a femoral tumor with the overlay of microPET and microCT images. (B) microPET/CT of a calvarial tumor. (C) microPET/CT of a tibial tumor. The most F18 avid area of tumor corresponds with an area of lesser osteoid formation as revealed by microCT. (D) Eight-week-old animals were assessed for tumor burden by N18F revealing a positive lesion on the lower jaw; animal on the left is Osx-Cre+p53fl/flpRbfl/fl, animal on the right is Osx-Cre−p53fl/flpRbfl/+. Arrows indicate OS lesion.