Table 2.
Frequency of vaccine-induced antibody responses.
| Group | Commercial ELISA | Commercial Western blot | ELISA EnvC | IP–Western blot |
|---|---|---|---|---|
| 2 mg (n = 5) | 0 (0) | 0 (0) | 1 (20) | 0 (0) |
| 4 mg (n = 20) | 11 (55) | 5 (25) | 12 (60) | 8 (40) |
| 8 mg (n = 15) | 3 (20) | 2 (13) | 11 (73) | 12 (80) |
| Placeboa (n = 8) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
NOTE. Data are no. (%) of subjects. IP, immunoprecipitation.
a
Two subjects who became infected with HIV, both in the placebo group, are not included in this table. All other subjects (n = 48) remained polymerase chain reaction (PCR) negative throughout the study. Aside from the results for the 2 HIV-infected subjects, the Western blot results were all in the indeterminate category. A positive Western blot result required a band at p24 in addition to a band for at least 1 of the envelope glycoproteins (gp41, gp120, or gp160). If there were bands present that did not meet the positivity criteria, the result was reported as indeterminate.