Table 5.

Frequency of subjects with positive T cell responses to the dose levels of 10⁹ particle units (PUs), 10¹⁰ PUs, and 10¹¹ PUs at 4 and 24 weeks after vaccination, as measured by intracellular cytokine staining (ICS) assay in CD4⁺ and CD8⁺ T cells and by enzyme-linked immunospot (ELISpot) assay in CD4⁺ or CD8⁺ T cells.

	Week 4			Week 24
Peptide pool	109 PUs	1010 PUs	1011 PUs	109 PUs	1010 PUs	1011 PUs
EnvA	90, 40, 70	80, 20, 60	80, 50, 70	40, 0, 20	20, 10, 10	80, 30, 60
EnvB	80, 60, 60	70, 40, 40	80, 50, 40	40, 0, 40	70, 10, 10	80, 40, 70
EnvC	60, 20, 60	60, 10, 30	90, 50, 60	10, 0, 10	20, 0, 10	80, 30, 60
Gag	50, 0, 40	40, 30, 20	60, 20, 10	20, 0, 0	20, 0, 0	30, 10, 30
Pol-1a	30, 40, 50	20, 10, 20	40, 20, 30	0, 0, 20	0, 0, 10	10, 30, 40
Pol-2a	30, 10, 40	40, 10, 20	40, 20, 30	10, 10, 10	10, 0, 0	30, 10, 30
Any	90, 60, 80	90, 50, 70	100, 70, 70	40, 10, 60	80, 10, 10	100, 60, 90

NOTE. Data are percentages for CD4⁺ T cells (ICS assay), CD8⁺ T cells (ICS assay), and CD4⁺ or CD8⁺ T cells (ELISpot assay) (n = 10 subjects/group).

^aPol protein is too large to include all peptides in 1 pool; therefore, the Pol peptides were divided into 2 pools.