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. 1978 Apr;35(4):659–662. doi: 10.1128/aem.35.4.659-662.1978

Lack of mutagenicity to Salmonella typhimurium of some Fusarium mycotoxins.

F C Wehner, W F Marasas, P G Thiel
PMCID: PMC242902  PMID: 348106

Abstract

The mutagenicity of eight Fusarium toxins (mono-, di-, and triacetoxyscirpenol, T-2 toxin, deoxynivalenol, 3-acetyl-deoxynivalenol, zearalenone, and moniliformin) and of two positive controls (aflatoxin B1 and sterigmatocystin) to histidine-requiring strains TA 98, 100, 1535, and 1537 of Salmonella typhimurium was tested both with and without metabolic activation. Both aflatoxin B1 and sterigmatocystin, but none of the eight Fusarium toxins, were mutagenic to S. typhimurium. The lack of mutagenic activity of T-2 toxin and diacetoxyscirpenol supports the negative results that have been obtained with in vivo carcinogenicity tests. The negative mutagenicity of the four other 12,13-epoxytrichothecenes tested, and of zearalenone and moniliformin, could not be correlated with in vivo tests because published accounts of their chronic toxicity were not available.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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