Skip to main content
PMC home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1989 Mar;65(761):140–143. doi: 10.1136/pgmj.65.761.140

Anticardiolipin antibody levels in diabetic subjects with and without coronary artery disease.

T J Hendra 1, E Baguley 1, E N Harris 1, M H Khamashta 1, R C Trembath 1, G R Hughes 1, J S Yudkin 1
PMCID: PMC2429247  PMID: 2813232

Abstract

Moderate (greater than 20 units) and high (greater than 80 units) IgG anticardiolipin antibody (aCL) titres are strongly predictive for recurrent thrombosis and early myocardial infarction in non-diabetic subjects. We have tested the hypothesis that the excess risk of myocardial infarction in diabetic subjects relates to the presence of aCL by measuring the frequency and titre of aCL in two groups of diabetic subjects and in 2500 healthy controls. One non-diabetic subject (0.04%) had low (5-20 units) IgG aCL titres. Seven out of 126 diabetics without cardiovascular disease (5.6%) and 9 out of 79 diabetics who were either myocardial infarction survivors or who had angiographically-proven coronary artery disease (11.4%) had low aCL titres (P less than 0.01 for comparison of either diabetic group with controls, and P less than 0.1 for comparison between diabetic groups). One subject in each diabetic group, but no non-diabetics, had moderate IgM aCL titres. No subjects had high aCL titres. Diabetics have an increased frequency of low aCL titres which may relate to macrovascular disease. Macrovascular disease in diabetics is not associated with moderate or high aCL titres.

Full text

PDF
142

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asherson R. A., Derksen R. H., Harris E. N., Bingley P. J., Hoffbrand B. I., Gharavi A. E., Kater L., Hughes G. R. Large vessel occlusion and gangrene in systemic lupus erythematosus and "lupus-like" disease. A report of six cases. J Rheumatol. 1986 Aug;13(4):740–747. [PubMed] [Google Scholar]
  2. Borch-Johnsen K., Kreiner S. Proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus. Br Med J (Clin Res Ed) 1987 Jun 27;294(6588):1651–1654. doi: 10.1136/bmj.294.6588.1651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cariou R., Tobelem G., Soria C., Caen J. Inhibition of protein C activation by endothelial cells in the presence of lupus anticoagulant. N Engl J Med. 1986 May 1;314(18):1193–1194. doi: 10.1056/NEJM198605013141817. [DOI] [PubMed] [Google Scholar]
  4. Carreras L. O., Defreyn G., Machin S. J., Vermylen J., Deman R., Spitz B., Van Assche A. Arterial thrombosis, intrauterine death and "lupus" antiocoagulant: detection of immunoglobulin interfering with prostacyclin formation. Lancet. 1981 Jan 31;1(8214):244–246. doi: 10.1016/s0140-6736(81)92087-0. [DOI] [PubMed] [Google Scholar]
  5. Fuller J. H., Keen H., Jarrett R. J., Omer T., Meade T. W., Chakrabarti R., North W. R., Stirling Y. Haemostatic variables associated with diabetes and its complications. Br Med J. 1979 Oct 20;2(6196):964–966. doi: 10.1136/bmj.2.6196.964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Garcia M. J., McNamara P. M., Gordon T., Kannel W. B. Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study. Diabetes. 1974 Feb;23(2):105–111. doi: 10.2337/diab.23.2.105. [DOI] [PubMed] [Google Scholar]
  7. Hamsten A., Norberg R., Björkholm M., de Faire U., Holm G. Antibodies to cardiolipin in young survivors of myocardial infarction: an association with recurrent cardiovascular events. Lancet. 1986 Jan 18;1(8473):113–116. doi: 10.1016/s0140-6736(86)92258-0. [DOI] [PubMed] [Google Scholar]
  8. Harris E. N., Asherson R. A., Gharavi A. E., Morgan S. H., Derue G., Hughes G. R. Thrombocytopenia in SLE and related autoimmune disorders: association with anticardiolipin antibody. Br J Haematol. 1985 Feb;59(2):227–230. doi: 10.1111/j.1365-2141.1985.tb02988.x. [DOI] [PubMed] [Google Scholar]
  9. Harris E. N., Chan J. K., Asherson R. A., Aber V. R., Gharavi A. E., Hughes G. R. Thrombosis, recurrent fetal loss, and thrombocytopenia. Predictive value of the anticardiolipin antibody test. Arch Intern Med. 1986 Nov;146(11):2153–2156. [PubMed] [Google Scholar]
  10. Hasselaar P., Derksen R. H., Blokzijl L., de Groot P. G. Thrombosis associated with antiphospholipid antibodies cannot be explained by effects on endothelial and platelet prostanoid synthesis. Thromb Haemost. 1988 Feb 25;59(1):80–85. [PubMed] [Google Scholar]
  11. Morton K. E., Gavaghan T. P., Krilis S. A., Daggard G. E., Baron D. W., Hickie J. B., Chesterman C. N. Coronary artery bypass graft failure--an autoimmune phenomenon? Lancet. 1986 Dec 13;2(8520):1353–1357. doi: 10.1016/s0140-6736(86)92004-0. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES