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. Author manuscript; available in PMC: 2009 May 31.
Published in final edited form as: Eur J Pharmacol. 2008 Feb 29;586(1-3):106–113. doi: 10.1016/j.ejphar.2008.02.073

Fig. 4. Isoflurane decreases the activation of caspase 3 in the ischemic penumbra after the permanent right middle cerebral arterial occlusion (MCAO).

Fig. 4

Rats were exposed to or not exposed to 2% isoflurane for 30 min before the MCAO. The left frontal cortex area 1 (non-ischemia), right frontal cortex area 1 (penumbra) and right parietal cortex area 1 (ischemic core) were harvested for Western blotting of the active caspase 3 (the 20 KDa form). A representative Western blot is shown on the top panel and the graphic presentation of the active caspase 3 protein abundance quantified by integrating the volume of autoradiograms from 5 to 7 rats is shown in the bottom panel. Values in graphs are expressed as fold change over the rats subjected to the MCAO only and presented as the means ± S.D. * P < 0.05 compared with the MCAO only. Iso P: isoflurane preconditioning.