Figure 7. Concomitant Mapping of Mutation and Methylation of CAN Genes in Human Breast and Colon Cancers.

(A) Results for breast CAN genes. Gene names are listed at the right of the map. For each gene, the methylation and mutational status is shown for the 11 breast cell lines that were subject to large-scale sequencing described by Sjoblom et al. [7] and normal breast tissue. Green indicates no methylation or mutation detected. Red indicates complete methylation or homozygous mutation. Orange denotes heterozygous mutation or partial methylation.

(B) Results for colon CAN genes. Data are presented in the same format as in (A).