Figure 8. Functional Associations of Common Target Genes.

Functional associations of genes were determined using Gene Ontology (GO) groups and available literature. Evidence for tumor suppressor function was scored positive if reports in the literature show that the gene of interest can suppress growth of cancer cells in vitro, in vivo, or in murine genetic models, or modulate known tumor suppressor function. loc., location. Known cancer susceptibility location was scored positive if evidence exists in the literature for LOH or homozygous deletion in primary human tumors at the region shown using either standard genetic mapping or comparative genomic hybridization (CGH) analysis (shaded).