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. 2008 May 27;5(5):e114. doi: 10.1371/journal.pmed.0050114

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Copyright: © 2008 Chan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Hypermethylation of selected common target genes by grade and stage in primary breast tumors. The first graph shows the frequency of methylation of at least one of the three genes listed in low- versus high-grade breast tumors. The second (SYNE1) and third (COL7A1) graphs show the frequency of methylation of the indicated genes in different stages of breast cancer. p-Values are adjusted using the Holm method.